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Podcast: A Brief History of Gene Therapy and the Discovery of DNA

Podcast: How Does Gene Therapy Work? Correcting Disease-Causing Genetic Variations

Newborn & Prenatal Genetic Screening

  • Resources
    • Downloadable Resources
    • Glossary
    • Gene Therapy Clinical Trials in the U.S.
  • About
  • Resources
    • Downloadable Resources
    • Glossary
    • Gene Therapy Clinical Trials in the U.S.
  • About
gtn
  • Overview of Gene Therapy
    • What Is Gene Therapy?
    • Gene Manipulation Strategies
    • Delivery of Gene Therapy
    • History of Gene Therapy
    • Overcoming Challenges in Gene Therapy
  • Monogenic and Complex Diseases
      • Monogenic Diseases
          • Overview of Monogenic Diseases
          • Classifications of Monogenic Diseases
          • Four Types of Genetic Alterations
          • Treatment Strategies of Monogenic Diseases – Protein
          • Treatment Strategies of Monogenic Diseases – Substrate
          • Treatment Strategies of Monogenic Diseases – RNA
          • Treatment Strategies of Monogenic Diseases – DNA
      • Complex Diseases
          • Overview of Complex Diseases
          • Treatment Strategies in Cancer
          • Overview of Cancer
          • Overview of Gene Therapy as a Treatment Strategy in Cancer
  • Safety of Gene Therapy
      • Immnogenicity of Gene Therapies
          • Immnogenicity of Gene Therapies
          • Immunogenicity of Lentiviral Vectors
          • Immunogenicity of Adeno-Associated Viral Vectors
          • Impact of the Immune Response on Gene Therapy
          • Strategies to Avoid the Host Immune Response
          • Immunogenicity Profiles of Selected Gene Therapies
      • Vector Shedding
          • Overview of Viral Vector Shedding
          • Factors Influencing Vector Shedding
          • AAV Vector Shedding Data in Clinical Trials
  • PracticalConsiderations
      • Considerations for Working with In Vivo Gene Therapies
          • FAQ: Considerations for Working with In Vivo Gene Therapies
      • Protocols for Handling Gene Therapy Products
          • Handling Gene Therapy in Clinical Settings
          • Institutional Preparedness for Handling In Vivo Gene Therapy
          • Receipt, Storage, Preparation, and Dispensing of In Vivo Gene Therapy
          • Transport and Administration of In Vivo Gene Therapy
          • Waste Disposal and Decontamination Following the Preparation and Administration of In Vivo Gene Therapy
          • Addressing Spills and Accidental Exposure to In Vivo Gene Therapy
  • Gene TherapyApproaches
      • Gene Replacement Therapy
          • What is Gene Replacement Therapy
          • Monogenic Diseases – A Therapeutic Target for Gene Replacement Therapy
      • Gene Inhibition Therapy
          • Overview of Gene Inhibition Therapy
          • Endogenous RNAi Pathway
          • Therapeutic Triggers of RNAi
          • shRNA Versus Artificial miRNA
          • Components of Gene Inhibition Therapy
      • Genetic Modulation of Immune Cells
          • Genetic Modulation of Immune Cells: Overview
          • Introduction to Genetically Engineered T Cells
          • CAR T-cell Therapy: How Does It Work?
          • TCR Therapy: How Does It Work?
          • Gene-Based Vaccines: How Do They Work?
          • Cytokine Gene Transfer: How Does It Work?
      • Genome Editing
          • Overview of Genome Editing
          • CRISPR-Cas9 Genome Editing
      • Gene Addition
          • How Does Gene Addition Work?
  • Current Therapeutics & Research
    • Gene Therapies in Research: Overview
    • Approved Therapies
  • Expert Series
    & Podcasts
      • Expert Series: Preparing Your Institution for Gene Therapy
          • Meet the Experts: Preparing Your Institution for Gene Therapy
          • Expert Series: Organizational Challenges
          • Expert Series: Institutional Preparedness
          • Expert Series: Engineering Controls and Physical Facilities
          • Expert Series: Handling and Exposure
      • Podcasts
          • A Brief History of Gene Therapy and the Discovery of DNA
          • How Does Gene Therapy Work? Correcting Disease-Causing Genetic Variations

The GTnetwork Podcast Series

EPISODE 1 | 12:08 MINUTES

A Brief History of Gene Therapy and the Discovery of DNA

Explore some of the major scientific findings – like discovering DNA – that set the stage for gene therapy, and its groundbreaking potential in the treatment of genetic diseases.

LISTEN
EPISODE 2 | 10:03 MINUTES

How Does Gene Therapy Work? Correcting Disease-Causing Genetic Variations

While some genetic variations are positive, others can cause or contribute to disease. Learn how gene therapy replaces and repairs certain gene variants, and is changing the trajectory of genetic diseases.

LISTEN

Website Navigation

  • Overview of Gene Therapy
    • What is Gene Therapy
    • Gene Manipulation Strategies
    • Delivery of Gene Therapy
    • History of Gene Therapy
    • Overcoming Challenges in Gene Therapy
  • Monogenic and Complex Diseases
    • Monogenic Diseases
      • Overview of Monogenic Diseases
      • Classifications of Monogenic Diseases
      • Four Types of Genetic Alterations
      • Treatment Strategies
        • Treatment Strategies of Monogenic Diseases – Protein
        • Treatment Strategies of Monogenic Diseases – Substrate
        • Treatment Strategies of Monogenic Diseases – RNA
        • Treatment Strategies of Monogenic Diseases – DNA
    • Complex Diseases
      • Overview of Complex Diseases
      • Overview of Cancer
      • Treatment Strategies in Cancer
  • Safety of Gene Therapy
    • Immunogenicity of Gene Therapies
      • Immunogenicity of Lentiviral Vectors
      • Immunogenicity of Adeno-Associated Viral Vectors
      • Impact of the Immune Response on Gene Therapy
      • Strategies to Avoid the Host Immune Response
      • Immunogenicity Profiles of Selected Gene Therapies
    • Overview of Viral Vector Shedding
    • Factors Influencing Vector Shedding
    • AAV Vector Shedding Data in Clinical Trials
  • PracticalConsiderations
    • FAQ: Considerations for Working with In Vivo Gene Therapies
    • Handling Gene Therapy in Clinical Settings
    • Protocols for Handling Gene Therapy Products
      • Institutional Preparedness for Handling In Vivo Gene Therapy
      • Receipt, Storage, Preparation, and Dispensing of In Vivo Gene Therapy
      • Transport and Administration of In Vivo Gene Therapy
      • Waste Disposal and Decontamination Following the Preparation and Administration of In Vivo Gene Therapy
      • Spills and Accidental Exposure
  • Gene TherapyApproaches
    • Gene Replacement Therapy
      • What is Gene Replacement Therapy
      • Monogenic Diseases – A Therapeutic Target for Gene Replacement Therapy
    • Gene Inhibition Therapy
      • Overview of Gene Inhibition Therapy
      • Endogenous RNAi Pathway
      • Therapeutic Triggers of RNAi
      • shRNA Versus Artificial miRNA
      • Components of Gene Inhibition Therapy
    • Genetic Modulation of Immune Cells
      • Genetic Modulation of Immune Cells: Overview
      • Introduction to Genetically Engineered T Cells
      • CAR T-cell Therapy: How Does It Work
      • TCR Therapy: How Does It Work
      • Gene-Based Vaccines: How Do They Work
      • Cytokine Gene Transfer: How Does it Work
    • Genome Editing
      • Overview of Genome Editing
      • CRISPR-Cas9 Genome Editing
    • Gene Addition
      • How Does Gene Addition Work
  • Current Therapeutics & Research
    • Gene Therapies in Research: Overview
    • Approved Therapies
  • Expert Series & Podcasts
    • Expert Series
      • Meet the Experts: Preparing Your Institution for Gene Therapy
      • Expert Series: Institutional Preparedness
      • Expert Series: Organizational Challenges
      • Expert Series: Engineering Controls and Physical Facilities
      • Expert Series: Handling and Exposure
    • Podcasts
      • A Brief History of Gene Therapy and the Discovery of DNA
      • How Does Gene Therapy Work? Correcting Disease-Causing Genetic Variations

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